84-2337-03　［取扱停止］FZR1 (CDC20 like 1b, CDC20 like Protein 1, CDC20-like Protein 1, CDC20C, CDH1, Cdh1/Hct1 Homolog, Fizzy Related Protein 1, Fizzy Related Protein, Fizzy Related Protein Homolog, Fizzy-Related Protein Homolog, Fizzy/Cell Division Cycle 20 Related 1, FYR, FZR 1, FZR 2, Fzr, FZR_HUMAN, Fzr1, Fzr1 Protein, FZR2, HCDH 1, HCDH, hCDH1, KIAA1242) 50ul　222815

特徴

• Fizzy-related protein, known as fzr, is a conserved eukaryotic gene that has been recently identified as a 7WD domain family member and is implicated in cell cycle regulation of Drosophila and yeast.
• Retroviral overexpression of fzr in B-lymphoma cells reduces tumor formation.
• Fzr overexpression increases B-lymphoma cell susceptibility to natural killer cell (NK) cytotoxicity.
• Fzr has been implicated in a new category of genes which suppress B-cell tumorigenesis.
• Current research suggests a novel role for fzr in the target cell interaction with NK cells.
• Fzr also negatively regulates the levels of cyclins A, B and B3.
• Loss of fzr causes progression through an extra division cycle in the epidermis and inhibition of endoreduplication in the salivary gland, in addition to failure of cyclin removal.
• Conversely, premature fzr overexpression downregulates mitotic cyclins, inhibits mitosis and transforms mitotic cycles into endoreduplication cycles.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.