FUCA1 (fucosidase, alpha-L-1, tissue) is a 466 amino acid membrane- and seminalassociatedis ozyme that is a member of the glycosyl hydrolase 29 family
FUCA1 functions as a homotetramer and is responsible for hydrolyzing and reducing the carbohydrate moieties of glycoproteins in various tissues.
Defects in the gene encoding FUCA1 result in fucosidosis, an autosomal recessive disordercaused by an accumulation of fucose-containing glycolipids and glycoproteins.Fucosidosis, a lysosomal storage disease, is characterized by neurologic deterioration, growth retardation, visceromegaly, and seizures.
Early onset of fucosidosis causes coarse facial features, angiokeratoma corporisdiffusum, spasticity, delayed psychomotor development and an unusual spondylometaphyseoepiphyseal dysplasia.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of FUCA1. Species Crossreactivity: Human
