The Fox family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain.
FOXN1, also designated Transcription factor winged-nude (WHN), is required for keratinocyte growth, as well as differentiation of epithelial progenitor cells in the thymic primordium into subcapsular, cortical, and medullary epithelial cells of the mature thymus.
Mutations in the FOXN1 gene are responsible for nude, immune-deficient mice and rats.
These nude mice are useful as hosts for xenografts in cancer research.
The promoters for FOXN1 are active in the skin and thymus reflecting the critical role FOXN1 plays in the proper development of these tissues.
Secreted Wnt glycoproteins appear to regulate FOXN1 transcription in the thymus.
FOXN1 is expressed in the embryonic thymus after the common primordium is formed, beginning at E11.25.
FOXN1 is also expressed at very low levels in normal human kidney and thyroid gland.
In human, it is also expressed in the differentiating cells of the hair follicle precortex, the innermost layer of the outer root sheath, and the thymus.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of FOXN1. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to residues in Human FOXN1.
