84-2334-91　［取扱停止］FKBP1A (12 a FK506-Binding Protein, 12 a FKBP, FK506 Binding Protein 1, FK506 Binding Protein 12, FK506 Binding Protein 1A 12 a, FK506 Binding Protein 1A, FK506 Binding Protein T Cell 12, FK506-Binding Protein 1A, FKB1A, FKBP 12, FKBP 1A, FKBP-12, FKBP-1A, FKBP1, FKBP12, FKBP12 Exip3, FKBP12C, FKBP1A, Immunophilin FKBP12, Peptidyl prolyl cis trans Isomerase, Pepti ...　222705

特徴

• Immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases which bind to and mediate the effects of immunosuppressive drugs such as Cyclosporin, FK506 and Rapamycin.
• The prototypic member of the family, FKBP12, was originally identified as a target of FK506 and Rapamycin activity.
• FKBP12 is an abundant, evolutionarily conserved cytoplasmic protein.
• Although the molecular role of FKBP12 activity is not well understood, the protein has been implicated as a regulator of diverse array of cellular processes including T cell activation, entry into the cell cycle and intracellular calcium release.
• Interestingly, FKBP12 has been shown to associate with the intracellular cytoplasmic domain of the type I TGFbeta receptor.
• This association is constitutive and not dependent on the activation of the receptor.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.