Fibulin-1 is a modular glycoprotein component of the elastic extracellular matrix fibers, basement membranes and blood.
Fibulin-1 self associates as well as binds to calcium, fibronectin, laminin, nidogen and fibrinogen.
These interactions, individually or in combination, may account for the observed association of Fibulin-1 with basement membranes, connective tissue, elastic fibers and fibrin clots.
Fibulin-1 expression is stimulated by estrogen in ovarian cancer cell lines and has been suggested as both an agent of metastasis in ovarian cancer cells and an indicator for predicting cancer risk or aggressiveness in ovarian carcinomas.
Other studies point to the inhibition of cancer cell motility with increasing exposure to Fibulin-1.
The exact function of Fibulin-1 in the cell is unknown.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of Fibulin-1. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to residues in Human Fibulin-1.
