FGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family containing an Ig-like domain and a tyrosine kinase domain.
This receptor has multiple isoforms and is a Type I membrane protein.
FGFR1 is a widely expressed membrane receptor, with distinct isoforms expressed in specific tissues.
FGFR1 binds fibroblast growth factor and induces mitogenesis and cellular differentiation.
Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis.
FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform.
FGFR1 has been shown to interact with N-cadherin and NCAM.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of FGFR1. Species Crossreactivity: Human, mouse, rat
