84-2333-71　［取扱停止］FCGR1A (CD64, CD64A, Fc fragment of IgG high affinity Ia Receptor (CD64), Fc gamma Receptor, Fc gamma Receptor I A1, Fc gamma RI, Fc gamma RIA, Fc-gamma RI, Fc-gamma RIA, FCG1, FcgammaRIa, FCGR1, FCGR1, FCGR1A, FcRI, FLJ18345, High affinity immunoglobulin gamma Fc Receptor I, IGFR1, IgG Fc Receptor I) 50ul　222646

特徴

• Three different classes of IgG Fc receptors have been described: FcyRI (CD64), FcyRII (CD32) and FcyRIII (CD16).
• The low affinity receptors, CD64 and CD16, have a putative role in mediating humoral immune responses.
• CD64 is a surface glycoprotein with high affinity for monomeric IgG, is expressed constitutively on monocytes and macrophages, and can be induced in neutrophils subsequent to IFN-y stimulation.
• CD64 plays a putative role in the initiation of cell-mediated cytotoxicity.
• Thus far, three genes encoding four distinct CD64 transcripts have been described.
• CD64 has been shown to associate with signal transducing subunit of the high affinity IgE receptor.
• Src family kinases Hck and Lyn show increased kinase activity and will co-immunoprecipitate with CD64 subsequent to receptor cross linking.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.