84-2333-63 ［取扱停止］FBXW7 (AGO, Archipelago, Archipelago Homolog, Archipelago, Drosophila, Homolog of, CDC4, CDC4, S.cerevisiae, Homolog of, DKFZp686F23254, F box and WD 40 Domain Protein 7 (archipelago Homolog, Drosophila), F box and WD 40 Domain Protein 7, F box and WD Repeat Domain Containing 7, F box Protein FBW7, F box Protein FBX30, F box Protein SEL 10, F box Protein SEL10, F- ... 222642
84-2333-63 ［取扱停止］FBXW7 (AGO, Archipelago, Archipelago Homolog, Archipelago, Drosophila, Homolog of, CDC4, CDC4, S.cerevisiae, Homolog of, DKFZp686F23254, F box and WD 40 Domain Protein 7 (archipelago Homolog, Drosophila), F box and WD 40 Domain Protein 7, F box and WD Repeat Domain Containing 7, F box Protein FBW7, F box Protein FBX30, F box Protein SEL 10, F box Protein SEL10, F- ... 222642
The F-box protein family is characterized by an ~40 amino acid motif known as the F-box.
F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.
One family member, Cdc4, also known as AGO, FBW7, FBXW7, FBX30, SEL10, and FLJ11071, maps to human chromosome 4q31.3.
Alternative splicing of this gene generates four transcript variants.
In addition to an F-box, Cdc4 contains seven tandem WD40 repeats.
Cdc4 binds directly to cyclin E and targets cyclin E for ubiquitin-mediated degradation.
Mutations of the Cdc4 gene are detected in ovarian and breast cancer cell lines, suggesting that the gene may be involved in the pathogenesis of human cancers.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of FBXW7. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant full length Human FBXW7.
Shelf Life：1year
Swiss Prot Number：Q969H0
EU Commodity Code：30021010
商品名：FBXW7 (AGO, Archipelago, Archipelago Homolog, Archipelago, Drosophila, Homolog of, CDC4, CDC4, S.cerevisiae, Homolog of, DKFZp686F23254, F box and WD 40 Domain Protein 7 (archipelago Homolog, Drosophila), F box and WD 40 Domain Protein 7, F box and WD Repeat Domain Containing 7, F box Protein FBW7, F box Protein FBX30, F box Protein SEL 10, F box Protein SEL10, F-box and WD Repeat Domain Containing 7, E3 Ubiquitin Protein Ligase, F-box and WD-40 Domain-Containing Protein 7, F-box Protein FBX30, F-box/WD Repeat-Containing Protein 7, FBW6, FBW7, FBX30, FBXO30, FBXW6, FBXW7, FBXW7_HUMAN, FLJ16457, hAgo, hCdc4, Homolog of C elegans sel 10, Homolog of C.elegans sel10, SEL 10, SEL-10, SEL10) 50ul
