84-2333-57　［取扱停止］FBXO11 (F box Protein 11, F-box only Protein 11, FBX11, FBX11_HUMAN, Fbxo11, PRMT9, Protein Arginine N Methyltransferase 9, Ubiquitin Protein Ligase E3 Component n recognin 6, UBR6, UG063H01, VIT-1, VIT1, Vitiligo Associated Protein VIT 1, Vitiligo-Associated Protein 1) 50ul　222639

特徴

• F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein)type E3 ubiquitin ligase complex and are involved in substrate recognitionand recruitment for ubiquitination.
• They are members of a larger familyof proteins that are involved in the regulation of a wide variety of cellularprocesses (including the cell cycle, immune responses, signaling cascadesand developmental events) through the targeting of proteins, such as cyclins,cyclin-dependent kinase inhibitors, IκB-alpha and beta-catenin, for proteasomal degradation.
• FBXO11 (F-box only protein 11), also known as VIT1 (vitiligoassociated protein 1), is a 927 amino acid nuclear protein that contains one UBR-type zinc finger, one F-box domain and 19 PbH1 repeats.
• Involved in protein ubiquitination, FBXO11 functions as a substrate recognition component of the SCF complex and is thought to bind to and inhibit the transcriptional activity of p53.
• Reduced expression of FBXO11 is associated with vitiligo, a disease characterized by progressive skin depigmentation.
• Multiple isoforms of FBXO11 exist due to alternative splicing events.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.