84-2333-28　［取扱停止］FANCG (NA Repair Protein XRCC9, DNA-Repair Protein XRCC9, FAG, FANCG, FANCG_HUMAN, Fanconi anaemia complementation group G, Fanconi anemia group G Protein, Protein FACG, X ray Repair, Complementing defective, in Chinese hamster Cells 9, X-Ray Repair, Complementing defective, in Chinese hamster, 9, XRCC9,) 100ul　222623

特徴

• Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromosomal instability.
• At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents.
• At least 8 complementation groups (A-G) have been identified and 6 FA genes (for subtypes A, C, D2, E, F, and G) have been cloned.
• The FA proteins lack sequence homologies or motifs that could point to a molecular function.
• The cellular accumulation of FA proteins, including FANCA and FANCG, is subject to regulation by TNF-alpha signaling.
• Phosphorylation of FANC (fanconi anemia complementation group) proteins is thought to be important for the function of the FA pathway.
• Phosphorylation of serine 7 in FANCG is functionally important in the FA pathway.
• FANCG is localized majorly in the nucleus and minorly in the cytoplasm,and is highly expressed in testis and thymus.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.