FAIM2 (Fas apoptotic inhibitory molecule 2), also known as LFG (Protein lifeguard), TMBIM2 (Transmembrane BAX inhibitor motif-containing protein 2) and NMP35 (neural membrane protein 35), is a 316 amino acid multipass membrane protein that uniquely protects cells from Fas-induced apoptosis.
Though widely expressed, FAIM2 expression is highest in hippocampus.
FAIM2 contains seven transmembrane domains and resembles Bax Inhibitor-1, another anti-apoptotic protein.
Overexpression of FAIM2 results in decreased caspase activation and reduced incidence of programmed cell death.
Though mechanistically related to the Fas signal, FAIM2 does not protect cells from apoptosis that is mediated by TNF-alpha signaling.
FAIM2 specifically regulates apoptosis by binding to the FAS receptor.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of FAIM2. Species Crossreactivity: Human
