84-2331-25　［取扱停止］ERCC5 (COFS 3, COFS3, DNA excision Repair Protein ERCC 5, DNA excision Repair Protein ERCC-5, DNA excision Repair Protein ERCC5, DNA Repair Protein Complementing XP G Cells, DNA Repair Protein Complementing XP-G Cells, DNA Repair Protein Complementing XPG Cells, ERCC 5, ERCC5, ERCC5, ERCM 2, ERCM2, Excision Repair Cross Complementing Rodent Repair Deficiency, Exci ...　222522

特徴

• Seven complementation groups (A-G) of xeroderma pigmentosum have been described.
• The xeroderma pigmentosum group A protein, XPA, is a zinc metalloprotein which preferentially binds to DNA damaged by ultraviolet (UV) radiation and chemical carcinogens.
• XPA is a DNA repair enzyme that has been shown to be required for the incision step of nucleotide excision repair.
• XPG (also designated ERCC5) is an endonuclease that makes the 3’ incision in DNA nucleotide excision repair.
• Mammalian XPG is similar in sequence to yeast RAD2.
• Conserved residues in the catalytic center of XPG are important for nuclease activity and function in nucleotide excision repair.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.