84-2330-91　［取扱停止］ErbB-4 (4ICD, Avian erythroblastic Leukemia Viral Oncogene Homolog 4, Avian erythroblastic Leukemia Viral v erb b2 Oncogene Homolog 4, E4ICD, EC 2.7.10.1, ErbB4, ERBB4 intraCellular Domain, ERBB4, HER 4, HER4, Mer4, MGC138404, Oncogene ERBB4, P180erbB4, Proto-Oncogene-like Protein c-ErbB-4, Receptor Protein Tyrosine Kinase erbB 4 Precursor, Receptor Tyrosine Prote ...　222505

特徴

• The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas.
• Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding.
• The gene encoding ErbB-4 is expressed as a full length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment.
• The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate.
• Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin.
• ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum.
• Applications:Suitable for use in Immunofluorescence, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:50-1:200 Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.