84-2330-76　［取扱停止］ERAB (3-hydroxyacyl-CoA Dehydrogenase Type-2, 17-beta-hydroxysteroid Dehydrogenase 10, 17-beta-HSD 10, 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase, 3-hydroxyacyl-CoA Dehydrogenase Type II, Endoplasmic Reticulum-Associated Amyloid beta-peptide-Binding Protein, Mitochondrial ribonuclease P Protein 2, Mitochondrial RNase P Protein 2, Short-Chain Type Dehydrogenase/Re ...　222498

特徴

• beta-Amyloid is a neurotoxic peptide that is associated with the pathogenesis of Alzheimer’s disease.
• beta-Amyloid aggregates induce cell death of neurons through the disruption of cell membranes and the generation of reactive oxygen intermediates.These neurotoxic effects are also attributed to the interaction of beta-Amyloid with intracellular proteins, specifically ERAB, the endoplasmic reticulum-associated beta-Amyloid-binding protein.
• ERAB is characterized as a NAD+-dependent dehydrogenase that is constitutively expressed in tissues and overexpressed in neurons affected in Alzheimer’s disease.
• Cells overexpressing ERAB in vitro have been shown to be more sensitive to beta-Amyloid-induced stress, and blocking the activity of ERAB has been shown to inhibit this cell death, indicating that beta-Amyloid induced cell death is mediated by ERAB.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.