Enhancer of Polycomb 1 (EPC1) is a member of the Polycomb group (PcG) proteins.
EPC1 interacts with the transcriptional repressor E2F6.
In proliferating cells, the proliferation-specific PcG, EZH2, associates with this E2F6-EPC1 complex, which may regulate genes required for cell cycle promotion.
EPC1 also interacts with a member of the RING finger protein family (RFP), and this complex functions as a transcriptional repressor.
Lastly, EPC1 is a com-ponent of the NuA4 histone acetyltransferase (HAT) complex, which transcriptionally activates certain genes by acetylation of Histones H4 and H2A.
This acetylation may alter nucleosome-DNA interactions and promote interaction of the modified histones with other positive transcription regulators.
The HAT complex may play a role in oncogene/proto-oncogene growth induction, tumor suppressor growth arrest, replicative senescence, apoptosis and DNA repair.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of EPC1. Species Crossreactivity: Human, mouse
