Members of the Ikaros family contain zinc-finger domains that are involved in DNA-binding and in the formation of homodimers and heterodimers between Ikaros family members.
Eos, also known as zinc finger protein Ikaros 4, is a 585 amino acid transcriptional repressor.
Localized to the nucleus, Eos may play a role in the development of the central and peripheral nervous systems.
Eos self-associates, forms heterodimers with Ikaros family members and interacts with CtBP2, PU.1 and MITF to repress transcription of cathepsin K and TRAP promoters.
Eos is expressed at low levels in kidney, thymus, liver and heart, and at high levels in skeletal muscle.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of human Eos. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa468-516 of human Eos.
