DPEP1 (dipeptidase 1), also known as MDP, RDP or MBD1, is a 411 amino acid renal protein that localizes to the apical cell membrane and belongs to the peptidase M19 family.
Existing as a disulfide-linked homodimer, DPEP1 uses zinc as a cofactor to catalyze the hydrolysis of various dipeptides and, via its catalytic activity, plays a role in glutathione and leukotriene metabolism.
DPEP1 is functionally inhibited by L-penicillamine and is subject to post-translational N-glycosylation.
The gene encoding DPEP1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome.
The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth.
The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of DPEP1. Species Crossreactivity: Human
