84-2324-27　［取扱停止］Dishevelled 3 (Segment polarity Protein dishevelled Homolog DVL-3, Dishevelled-3, Dishevelled3, DSH Homolog 3, DVL3, KIAA0208) 100ul　222167

特徴

• Mammalian homologs of the Drosophila dishevelled (Dsh) gene have been identified, including Dvl-1, Dvl-2 and Dvl-3.
• The mammalian dishevelled proteins contain three homologous domains, two of which are unrelated to any other known protein.
• The third region is homologous to the discs-large homology domain of Drosophila discs-large-1, a tumor suppressor protein.
• Like their Drosophila counterpart, the dishevelled proteins are thought to be in-volved in embryogenesis.
• Overexpression of Dvl-1 has been shown to inhibit the phosphorylation of tau by GSK-3b.
• This finding may prove to be important in Alzheimer’s studies, which have shown that tau is hyperphosphorylated.
• In Drosophila, Dsh is a component of the frizzled signaling pathway.
• Both mammalian dishevelled and frizzled proteins are components of the Wnt signalling pathway.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.