This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein.
The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins.
Overexpression of the encoded protein sensitizes tumor cells to apoptosis.
A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64.
Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of DIABLO. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant full length Human DIABLO.
Shelf Life：1year
Swiss Prot Number：Q9NR28
EU Commodity Code：30021010
商品名：DIABLO (DBLOH_HUMAN, DBOH, DBOH, diablo, Diablo Homolog (Drosophila), Diablo Homolog (Drosophila), Diablo Homolog, Diablo Homolog Mitochondrial, DIABLO S, DIABLO S, Direct IAP Binding Protein with low pI, Direct IAP Binding Protein with low pI, Direct IAP-Binding Protein with low pI, FLJ10537, FLJ25049, Mitochondrial, Mitochondrial Smac Protein, Second mitochondria derived Activator of caspase, Second mitochondria derived Activator of caspase, Second mitochondria-derived Activator of caspase, SMAC 3, Smac, Smac Protein, Smac Protein, SMAC3, SMAC3,) 100ul
