84-2323-97　［取扱停止］DHCR24 (24 dehydrocholesterol Reductase, 24-dehydrocholesterol Reductase, 3 beta hydroxysterol delta 24 Reductase, 3-beta-hydroxysterol delta-24-Reductase, DCE, Delta(24)-sterol Reductase, Desmosterol to cholesterol Enzyme, DHC24_HUMAN, DHCR24, Diminuto dwarf1 Homolog, Diminuto/dwarf1 Homolog, KIAA0018, Nbla03646, Seladin-1, SELADIN1, Selective AD indicator 1, Sel ...　222153

特徴

• Dehydrocholesterol reductase (DHCR) proteins are involved in cholesterol bio-synthesis.
• DHCR7, also designated sterol Delta-7 reductase or 7-DHC reductase, reduces the C7-C8 double bond of 7-dehydrocholesterol.
• It is a multi-pass membrane protein localizing to the endoplasmic reticulum (ER).
• Defects in the DHCR7 gene can cause Smith-Lemli-Opitz syndrome (SLOS), an autosomal recessive disorder of sterol metabolism.
• DHCR24 acts as a catalyst for the reduction of the Delta-24 double bond of sterol intermediates.
• DHCR24, also designated 3-b-hydroxysterol Delta-24 reductase or seladin-1, binds to FAD and is predominantly expressed in adrenal gland and brain.
• It is a single-pass membrane protein localizing to the ER or Golgi apparatus.
• Defects in the DHCR24 gene cause cause the autosomal recessive disorder desmosterolosis.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.