Defensins are a family of microbicidal and cytotoxic peptides which are made by neutrophils and are thought to be involved in host defense.
Defensins are abundant in the granules of neutrophils and are also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract and vagina.
There are six alpha-defensins, which are known as human neutrophil peptides (HNPs) in humans.
HNP-1,2,3 and 4 are found in the microbicidal granules of neutrophils; HNP-5 and HNP-6 are located in Paneth cells of the intestinal tract.
HNP-1 is found in the microbicidal granules of neutrophils and probably plays a role in phagocyte-mediated host defense.
HNP-1, HNP-2 and HNP-3, which comprise about 30% of the total granule protein of the neutrophil, are secreted by most normal individuals.
The HNP-1 protein is encoded by the a1-defensin (DEFA1) gene.
HNP-3 is encoded by the a3-defensin (DEFA3) gene.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of Defensin alpha3. Species Crossreactivity: Human
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to amino acids 30-70 of Human Defensin α3.
