84-2323-45　［取扱停止］DEC2 (Class E basic Helix-Loop-Helix Protein 41, bHLHe41, Class B basic Helix-Loop-Helix Protein 3, bHLHb3, Differentially expressed in chondrocytes Protein 2, hDEC2, Enhancer-of-split and hairy-Related Protein 1, SHARP-1, SHARP1, BHLHE41, BHLHB3, DEC2, SHARP1) 50ul　222127

特徴

• Human DEC1 is a 412 amino acid, basic helix-loop-helix (bHLH) containing protein that is involved in the control of proliferation and/or differentiation of several cell types including nerve cells, fibroblasts and chondrocytes.
• The bHLH region of DEC1 is structurally similar to the bHLH regions of the mammalian HES family, Drosophila hairy, and Enhancer of split m7.
• DEC1 is a novel direct target for cAMP in a wide range of cells, and is involved in the control of gene expression in cAMP-activated cells.
• DEC2, also known as SHARP1, is highly expressed in skeletal muscle and brain.
• The gene encoding human DEC2 maps to chromosome 12p11.23-p12.1.
• DEC1 and DEC2 play a role in regulating the mammalian molecular clock by suppressing the transcription of specific clock genes.
• Both DEC1 and DEC2 are detected in the suprachiasmimc nucleus in a circadian fashion.
• Brief light impulses induce the expression of DEC1 in a phase-dependent manner.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.