Vitamin D-binding protein (DBP) is a multi-functional serum protein that binds to the plasma membranes of numerous cell types and mediates a variety of cellular functions.
The locus of the DBP protein (also known as group-specific component protein or GC) is located at human chromosome 4q13.3.
DBP functions in organ-specific transportation of vitamin D and its metabolites to the various target organs of the vitamin D endocrine system.
In addition, DBP has immunomodulatory properties and is able to bind to the surface of leukocytes.
DBP binds to the plasma membrane through a chondroitin sulfate proteoglycan.
DBP serves as a co-chemotactic factor for C5a to enhance the chemotactic activity of C5a.
DBP can also bind to globular Actin with high affinity and is involved in the clearance of Actin from the blood.
DBP plays an important role in osteoclast differentiation.
The diverse cellular functions of DBP require its cell surface binding ability to mediate different biological processes.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of DBP. Species Crossreactivity: Human
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to amino acids 111-160 of Human DBP.
