Drebrins (Developmentally regulated brain proteins) are cytoplasmic proteins that bind F-actin in the brain and are involved in cell migration, extension of neuronal processes, and plasticity of dendrites.
There are three isoforms: two embryonic types (E1 and E2), and an adult type (A) that are generated by alternative RNA splicing from a single Debrin gene.
Drebrins are expressed mainly in brain neurons but are also found in skeletal muscle, heart, placenta, pancreas, and kidney.
Drebrin has been designated as a marker of the dendritic spine.
Decreases in Drebrin levels in the brain are associated with Alzheimer’s disease and Down syndrome.
The gene encoding for the human Drebrin protein is located on chromosome 5.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of DBN1. Species Crossreactivity: Human
