D-amino acid oxidase (DAAO) metabolizes exogenous D-amino acids that accumulate during aging and modulates the level of D-serine in the brain, acting as a detoxifying agent.
DAAO is specific for the D-configuration of amino acids and exhibits a preference for those with small, hydrophobic side chains and polar, aromatic and basic functional groups.
D-amino acid oxidase activator (G72) associates with and activates DAAO.
This 157 amino acid protein localizes to the Golgi apparatus.
The gene encoding for the protein, known as DAOA, maps to chromosome 13q33.2-13q34.
G72 is expressed in amygdala, spinal cord and testis.
The G72 protein, together with the associated protein DAAO, is often implicated in schizophrenia.
An overexpression of the G72 protein can be detected in schizophrenic brain samples.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of DAOA. Species Crossreactivity: Human
