84-2322-49　［取扱停止］Cytokeratin 84 (Cytokeratin-84, Keratin, Type II cuticular Hb4, Keratin-84, Keratin84, Short name=K84, Type II hair keratin Hb4, Type-II keratin Kb24, KRT84, KRTHB4) 100ul　222078

特徴

• The Keratin multigene family is made of “soft” epithelial cytokeratins and “hard” hair Keratins.
• While the epithelial cytokeratins are involved in the layering and formation of epithelia, the hair Keratins are responsible for creating nails and hair.
• There are two types of Keratins: the acidic class I Keratin proteins and the basic/neutral class II Keratin proteins.
• Keratin 84, also known as KRT84, HB4 or KRTHB4, is a 600 amino acid protein that is expressed in hair follicles.
• Keratin 84 is a basic/neutral type II Keratin protein which heterodimerizes with type I Keratins to create hair and nails.
• The gene encoding Keratin 84 maps to human chromosome 12 which encodes over 1,100 genes and comprises ~4.5% of the human genome.
• Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis and Kniest dysplasia.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.