84-2321-97　［取扱停止］Cytokeratin 14/16 (Keratin, Type I Cytoskeletal 14, Cytokeratin-14, Short name=CK-14, Keratin-14, Short name=K14, KRT14, CK-14, CK 14, CK14, Cytokeratin-14, Cytokeratin 14, Cytokeratin14, Keratin, Type I Cytoskeletal 16, Cytokeratin-16, Short name=CK-16, Keratin-16, Short name=K16, KRT16, KRT16A, CK-16, CK 16, CK16, Cytokeratin-16, Cytokeratin 16, Cytokeratin16) 50ul　222050

特徴

• In Bowen’s disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14.
• Mutations in the gene encoding human Cytokeratin 14 lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts.
• It is absent in noninvasive breast carcinomas and normal breast tissue.
• Mutations in the Cytokeratin 16 gene cause various diseases, including pachyonychia congenita type 1 (PC1), nonepidermolytic palmoplantar keratoderma (NEPPK) and unilateral palmoplantar verrucous nevus (UPVN).
• Applications:Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.