84-2321-95　［取扱停止］Cytokeratin 14 (Keratin, Type I Cytoskeletal 14, Cytokeratin-14, Short name=CK-14, Keratin-14, Short name=K14, KRT14, CK-14, CK 14, CK14, Cytokeratin-14, Cytokeratin 14, Cytokeratin14) 50ul　222049

特徴

• Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells.
• The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments.
• Cytokeratins are useful markers of tissue differentiation, and in addition they aid in the characterization of malignant tumors.
• In Bowen’s disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14.
• Mutations in the gene encoding human Cytokeratin 14 lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.
• Applications:Suitable for use in Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.