The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.
The CYP2C (CYPIIC) subfamily comprises a group of constitutively expressed genes, some phenobarbital-induced genes, and several genes associated with sex-specific expression.
Originally, at least 7 genes were assigned to the CYP2C subfamily, which maps to human 10q24.1-q24.3 and mouse chromosome 19.
Humans contain fewer genes in this cluster than do mice or rats.
Four genes are arranged in the following order and orientation along human chromosome 10: RBP4, CYP2C18, CYP2C19/CYP2C9, and CYP2C8.
The previsously identified CYP2C10 is an artifact of CYP2C9 and not a distinct isoform.
All of the CYP2C proteins localize to the endoplasmic reticulum.
Applications:Suitable for use in Immunofluorescence,, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:50-1:200Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of CYP2C8/9/18/19. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IF IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 100-150 of Human CYP2C8.
