84-2320-22　［取扱停止］CXXC1 (CFP 1, CFP1, CpG Binding Protein, CpG-Binding Protein, CXXC 1, CXXC Finger 1, CXXC Finger 1 PHD Domain, CXXC Finger Protein 1, CXXC Type zinc Finger Protein 1, CXXC-Type zinc Finger Protein 1, CXXC1, CXXC1_HUMAN, DNA Binding Protein with PHD Finger and CXXC Domain, hCGBP, HsT2645, PCCX 1, PCCX1, PHD Finger and CXXC Domain Containing Protein 1, PHD Finger an ...　221961

特徴

• The human genome contains discrete clusters of unmethylated CpG dinucleotides, called CpG islands, which contribute to the modulation of gene expression by binding transcription factors.
• Human CpG binding protein (CGBP), detected in K562 cells, is a widely expressed member of CpG binding proteins that requires the CpG dinucleotide to bind DNA.
• CGBP binds specifically to unmethylated CpG motifs and functions as a transcriptional activator.
• The CXXC domain of CGBP is conserved in DNA methyltransferase, human trithorax, and methyl-CpG binding protein (MBP), and is involved in DNA-binding.
• CGBP also contains several domains implicated in protein-protein interactions, such as a coiled-coil domain, and two PHD finger domains, the function of which remains to be determined.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.