84-2320-08　［取扱停止］CXCR1 (C-X-C Chemokine Receptor Type 1, CXC-R1, CXCR-1, CDw128a, High affinity interleukin-8 Receptor A , IL-8R A, IL-8 Receptor Type 1, CD_Antigen=CD181, CXCR1, CMKAR1, IL8RA) 50ul　221954

特徴

• IL-8 has been shown to function as a potent neutrophil chemostatic and activating peptide and is an important mediator of inflammatory diseases.
• Two distinct human IL-8 receptors, designated IL-8RA and IL-8RB have been characterized.
• Both are expressed at a high level on neutrophils and to a lesser extent on monocytes and myeloid cell lines.
• In addition, the IL-8RA subunit is expressed in T cells such as the Jurkat cell line.
• Both IL-8Rs are members of the seven-transmembrane domain rhodopsin superfamily of receptors and as such, couple G proteins for signal transduction.
• The two receptors share 77% amino acid identity.
• IL-8RA exhibits high-affinity binding for IL-8 and low-affinity MGSA binding, whereas IL-8RB has high-affinity binding for both IL-8 and MGSA.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.