84-2319-97　［取扱停止］CXADR (Coxsackievirus and adenovirus Receptor, CAR, Hcar, CVB3-Binding Protein, Coxsackievirus B-adenovirus Receptor, HCVADR, CXADR, CAR) 50ul　221949

特徴

• The coxsackie and adenovirus receptor (CAR) mediates viral infection by the binding of various adenoviruses through specific protein interactions.
• There is a high affinity between the viral knob domain and the extracellular amino- terminal domain (designated D1) of CAR.
• The D1 domain alone is sufficient for knob binding in transfected cells.
• Determining the specific interactions between CAR and adenoviruses is imperative in order to further develop gene therapy using viral hosts.
• CAR is expressed in many human and murine cell types.
• However, cells that express CAR at low levels are not efficiently infected by adenoviruses.
• Possible methods of avoiding this problem in certain cell types are by either supplementing CAR or modifying the Ad knob to bind to other receptors.
• Applications:Suitable for use in Western Blot, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunocytochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.