84-2319-35　［取扱停止］CSNK2A2 (Casein Kinase 2 alpha prime Polypeptide, Casein Kinase II alpha' Chain, Casein Kinase II Subunit alpha', CK II alpha', CK II, CK2A2, CKII, CSK22, CSNK2A1, CSNK2A2, FLJ43934, Protein Kinase CK2) 50ul　221918

特徴

• Casein kinase I (also designated CKI) and casein kinase II (CKII) compose a family of serine/threonine protein kinases which are present in all eukaryotes examined to date.
• Casein kinase I family members, which include casein kinase Ialpha, Iγ, I∂ and Ie, have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair.
• CKII is usually expressed as a tetrameric complex consisting of either an alpha2beta2 or an alphaalpha'beta2 structure.
• The a catalytic subunit is stimulated by the beta regulatory subunit, which undergoes autophosphorylation.
• Casein kinase II activity is high in the cytosol and nucleus of proliferating and differentiating cells.
• Casein kinase II is known to phosphorylate more than 100 different substrates including nuclear oncoproteins, transcription factors and enzymes involved in DNA metabolism.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.