84-2319-16　［取扱停止］CSE1L (Exportin 2, Exportin2, Exportin-2, Exp2, Cellular Apoptosis susceptibility Protein, Chromosome segregation 1-like Protein, Importin-alpha re-exporter, CSE1L, CAS, XPO2) 100ul　221907

特徴

• Normal tissues are characterized by a balance between cellular stasis, cell proliferation, cell differentiation and cell death.
• Aberrant regulation of any of these cell processes can result in cancer.
• Cell death during embryogenesis, tissue atrophy and normal tissue turnover is called apoptosis.
• This is characterized by cytoplasmic and nuclear condensation, nuclear disorganization and fragmentation of genomic DNA into 180-200 base pair oligomers.
• Several human cDNA fragments have been shown to render MCF-7 cells resistant to cell death induced by Pseudomonas exotoxin, Pseudomonas exotoxin-derived immunotoxins, diptheria toxin and tumor necrosis factor (TNF).
• One such fragment has proven to be the human homolog to the yeast chromosome segregation homolog, CSE1.
• Cloning of the full-length human cDNA has revealed a putative protein designated CAS, for cellular apoptosis susceptibility, that is 971 amino acids in length with 59% overall sequence homology as compared to yeast CSE1.
• CAS is highly expressed in testis and fetal liver.
• Applications:Suitable for use in Immunofluorescence, Western Blot, Immunoprecipitation, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Immunoprecipitation: 1:50-1:200Immunofluorescence: 1:50-1:200 Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.