84-2318-89　［取扱停止］CRP (C reactive Protein, C reactive Protein pentraxin Related, C-reactive Protein(1-205), CRP, CRP, CRP, MGC88244, Pentraxin 1, PTX 1, PTX1) 100ul　221893

特徴

• Pentraxins, which include C-reactive protein (CRP) and serum amyloid P component (SAP), are prototypic acute phase proteins.
• CRP and SAP are produced by liver epithelial cells and are characterized by a cyclic pentameric structure and calcium-dependent ligand binding.
• IL-6 is the major inducer of human CRP gene, and IL-1 and steroids can enhance this induction.
• Testosterone is required for the expression of CRP transgene in vivo, whereas testosterone is not required for expression of the SAP gene.
• During the acute-phase response, cytokine C5a acts with IL-6 and/or IL-1b to promote upregulation of the CRP and SAP genes.
• Both Stat3 and C/EBP are involved in mouse SAP gene expression, but only Stat3 is involved in mouse CRP gene expression.
• SAP binds to a variety of molecules, including autoantigens and chromatin.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.