Members of the M14 metallocarboxypeptidase protein family serve many diverse functions and are divided into three subfamilies based on structure, function and amino acid sequence similarity.
As a member of the A/B subfamily,CPA6 (Carboxypeptidase A6) is a 437 amino acid secreted, zinc-binding protein that contains a characteristic propetide at the amino terminus,which is cleaved off upon enzyme activation.
Although expressed broadly in embryonic tissues, CPA6 is found at highest levels in the adult olfactory bulb and epididymus.
CPA6 functions to cleave large C-terminal hydrophobic residues off of proteins and protein substrates and is likely involved in the extracellular processing of neuropeptides.
Mutations in the gene encoding CPA6 have been linked to Duane syndrome, a congential eye-movement disorder characterized by the abnormal development of cranial nerve VI (the abducens nerve).
There are three isoforms of CPA6 that exist as a result of alternative splicing events.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of CPA6. Species Crossreactivity: Human
