84-2317-53　［取扱停止］Contactin-3 (Contactin-3, Contactin3, Contactin 3, Brain-derived immunoglobulin Superfamily Protein 1, BIG-1, BIG1, Plasmacytoma-Associated neuronal Glycoprotein, CNTN3, KIAA1496, PANG) 50ul　221824

特徴

• Changes in synaptic efficacy can mediate crucial processes during learning and memory formation.
• Accumulating evidence implicates cell adhesion molecules in activity-dependent synaptic modifications associated with paired-pulse facilitation (PPF), long-term potentiation (LTP) and long-term depression (LTD).
• Among the cell adhesion molecules involved in these processes are the contactins.
• Contactins are immunoglobulin superfamily members that play a selective role in synaptic plasticity, PPF and LTD, and may regulate cell-cell interactions contributing to synaptic plasticity in conjunction with other synapse targeting molecules, including paranodin and phosphacan.
• In addition, contactins are essential components that control expression and distribution of Na+ channels in neurons, junctional attachment at the paranode, and ultimately the physiology of the myelinated nerve.
• The human Contactin 1 gene encodes a 1,018 amino acid protein.
• The human Contactin 3 gene encodes a 646 amino acid plasmacytoma-associated neuronal glycoprotein.
• The human Contactin 5 gene encodes a 1,100 amino acid neural adhesion molecule.
• The human Contactin 6 gene encodes a 1,028 amino acid neural adhesion molecule.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.