COL11A2 (collagen, type XI, alpha 2), also known as Collagen alpha2 Type XI, HKE5, PARP, STL3, DFNA13 or DFNB53, is a 1,736 amino acid secreted protein that contains one TSP N-terminal domain and is thought to play an essential role in fibrillogenesis, specifically by controlling the lateral growth of collagen fibrils.
Defects in the gene encoding COL11A2 are the cause of Stickler syndrome type 3 (STL3), autosomal recessive otospondylomegaepiphyseal dysplasia (OSMED), Weissenbacher-Zweymueller syndrome (WZS) and non-syndromic sensorineural deafness autosomal dominant type 13 (DFNA13).
Eight isoforms of COL11A2 exist due to alternative splicing events.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of COL11A2. Species Crossreactivity: Human, mouse
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to amino acids 1200-1250 of Human COL11A2.
