84-2316-87　［取扱停止］COL11A1 (COBA1, COL11A1, COLL6, Collagen alpha 1, Collagen alpha-1(XI) Chain, collagen XI alpha 1, collagen XI, alpha 1 Polypeptide, collagen, Type XI, alpha 1, STL2, STL3, XI Chain Precursor) 100ul　221791

特徴

• Collagen Type XI is an 1806 amino acid protein belonging to the fibrillar collagen family.
• Collagen Type XI is thought to play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.
• This protein forms trimers composed of three different chains: a 1(XI), a 2(XI), and a 3(XI).
• a 3(XI) is a post-translational modification of a 1(II).
• a 1(V) can also be found instead of a 3(XI).
• Collagen Type XI has three named isoforms (A,B,C) and additional isoforms seem to exist, stemming from alternative usage of exon IIA or exon IIB.
• Transcripts containing exon IIA or IIB are present in cartilage, but exon IIB is preferentially utilized in transcripts from tendon.
• Collagen Type XI contains a single collagen binding TSP N-terminal (TSPN) domain.
• Collagen Type XI is expressed in cartilage, placenta and some tumor or virally transformed cell lines.
• Isoform expression can be tissue specific.
• Defects in the COL11A gene are the cause of Stickler syndrome type 2 (STL2), or beaded vitreous type, due to the presence of irregularly thickened fiber bundles throughout vitreous cavity.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1:500-1:1000Immunohistochemistry (Paraffin): 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.