CLIC3 (chloride intracellular channel protein 3) is a member of the highly conserved family of chloride ion channels (CLICs) that function in both soluble and integral membrane forms.
Chloride channels regulate cellular traffic of chloride ions, a critical component of all living cells.
They are involved in membrane potential stabilization, signal transduction, cell volume regulation and organic solute transport.
CLIC3 is found in a variety of tissues but is highly expressed in placenta, brain and heart.
CLIC3 predominantly localizes to the nucleus and stimulates chloride ion channel activity when expressed in cells.
In addition, CLIC3 interacts with ERK 7 and may play a role in the regulation of cell proliferation.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, pH 7.2, 0.05% sodium azide.
Specificity：Recognizes endogenous levels of human CLIC3. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 31-80 of human CLIC3.
