CIB4 (calciumand integrin-binding familymember 4) is a 185 amino acid protein thatcontainsthree EF-hand domains.
CIB4 is closelyrelated to CIB (CIB has one less EF-hand domain),which isknown to bind to IntegrinalphaIIbeta in platelets and isinvolved in signal transduction.
The gene encoding CIB4mapsto human chromosome 2,which houses over 1,400 genes and comprises nearly 8% of the human genome.
Harlequin icthyosis, a rare andmorbid skin deformity, is associatedwithmutationsin the ABCA12 gene,while the lipidmetabolic disordersitosterolemia is associated with defectsin the ABCG5 and ABCG8 genes.
Additionally, an extremelyrare recessive genetic disorder, Alströmsyndrome, iscaused bymutationsin the ALMS1 gene,whichmaps to chromosome 2.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of CIB4. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to residues in Human CIB4.
