Choriogonadotropin is a hormone produced by the placenta in the first trimester of pregnancy and exists as a heterodimer formed from a unique beta chain and an alpha chain common to all gonadotropins.
The unique beta chain confers biological specificity to choriogonadotropin, luteinizing hormone and follicle stimulating hormone.
The secreted alpha subunit maps to human chromosome 6 and the beta subunit of choriogonadotropin maps to human chromosome 19.
Choriogonadotropin stimulates the ovaries to produce and maintain normal levels of the steroids essential for maintaining pregnancy, including estrogen and progesterone.
Choriogonadotropin is a member of the cystine knot growth-factor superfamily, a group of proteins that contain a distinct arrangement of six cysteine residues and are expressed in placenta.
The proper secretion and dimerization of choriogonadotropin depends on the conformation of the cystine knot, although biological activity is independent of this conformation.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of CGB. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 101-150 of Human CGB.
