Cryptic is a 224 amino acid member of the epidermal growth factor-Cripto-1/ FRL1/cryptic family that consists of extracellular and cell-associated proteins which function as co-receptors for the transforming growth factor b subfamily of proteins.
Cryptic is involved in the appropriate establishment of the left-right axis of the organism, and it may play a role in the development of mesoderm and/or neural patterning during gastrulation.
Loss-of-function mutations in CFC1, the gene encoding for Cryptic, are associated with human left-right laterality defects.
Defects in CFC1 also cause visceral heterotaxy (HTX2), an autosomal disease characterized by a variable group of congenital anomalies that include complex cardiac malformations such as conotruncal heart malformations that may lead to cardiac outflow tract defects, pulmonary atresia, double-outlet right ventricle, truncus arteriosus communis and aortic arch anomalies.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of CFC1B/CFC1. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to residues in Human CFC1B/CFC1.
