84-2314-21　［取扱停止］CFB (AHUS4, B Factor properdin, BF, BFD, C3 proaccelerator, C3 proactivator, C3/C5 convertase, CFAB, CFAB_HUMAN, CFB, Complement Factor B, Complement Factor B Bb fragment, FB, FBI12, GBG, Glycine Rich beta Glycoprotein, Glycine-Rich beta Glycoprotein, H2 Bf, H2BF, PBF2, Properdin Factor B,) 100ul　221654

特徴

• This gene encodes complement factor B, a component of the alternative pathway of complement activation.
• Factor B circulates in the blood as a single chain polypeptide.
• Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb.
• The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase.
• Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation.
• This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.
• This cluster includes several genes involved in regulation of the immune reaction.
• Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration.
• The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.