84-2313-83　［取扱停止］CDKN3 (Cyclin-Dependent Kinase Inhibitor 3, CDI1, CIP2, KAP, CDKN3) 50ul　221635

特徴

• Cyclin-dependent kinase inhibitor 3 (CDKN3), also designated Cdk2-associated dual specificity phosphatase, cyclin-dependent kinase interactor 1 (CDI1), CIP2, KAP or KAP1, belongs to the protein-tyrosine phosphatase family.
• CDKN3, a cyclin-dependent kinase inhibitor, interacts and dephosphorylates Cdk2 kinase, which prevents Cdk2 kinase activation.
• CDKN3 is important in cell cycle regulation.
• It is a dual specificity phosphatase that is active toward substrates which contain phosphotyrosine or phosphoserine residues.
• CDKN3 does not interact with Cdk4, but can interact with other cyclin-dependent kinases such as Cdc2, Cdk2 and Cdk3.
• The gene encoding for the CDKN3 protein maps to chromosome 14q22.
• This gene has been noted to be mutated, overexpressed or deleted in many cancers.
• Defects in the CDKN3 gene may may be implicated in hepatocellular carcinoma (HCC).
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.