84-2313-76　［取扱停止］CDK9 (Cyclin-Dependent Kinase 9, C-2K, Cell Division Cycle 2-like Protein Kinase 4, Cell Division Protein Kinase 9, Serine/threonine-Protein Kinase PITALRE, Tat-Associated Kinase Complex Catalytic Subunit, CDC2L4, TAK) 100ul　221631

特徴

• A family of proteins designated cyclin dependent kinases (Cdks) are critical regulators of cell cycle progression.
• Cdk family members, including Cdc2 p34, Cdk1–9, PISSLRE, KKIALRE, PITSLRE and PCTAIRE 1–3 are constitutively expressed throughout the cell cycle.
• Cdc2 p34 activity peaks during mitosis and Cdk2 activity rises in late G1 or early S phase.
• Cdk4 and Cdk6 are critically involved in G1 to S phase progression.
• The functions of Cdk3, Cdk5b, PISSLRE, KKIALRE and PCTAIRE 1–3 are less well defined.
• Cdk9 (also designated PITALRE) has been shown to specifically phosphorylate the retinoblastoma protein.
• The more recently cloned Drosophila protein, P-TEFb, is thought to be the homolog of mammalian PITALRE.
• P-TEFb has been shown to be required for HIV Tat transcriptional activation.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.