Cdk 5 is required for proper development of the mammalian central nervous system and is predominantly expressed in neurons.
Neuronal Cdk5 can be activated by two accessory proteins designated p35nck5a and p39nck5ai, which is also known as p39.
The human p39 gene maps to chromosome 2q35 and encodes a 367-amino acid, 39kDa protein.
p35 and p39 both share limited similarity to cyclins and may define a distinct family of cyclin-dependent kinase activating proteins.
During embryonic rat brain development, the expression pattern of p39 appears to have an inverse relationship to that of Cdk5 and p35, suggesting that these proteins may have region-specific and developmental stage-specific functions in rat brain.
p39 can localize to lamellipodial and fillopodial structures of cells and in growth cones of neurons.
In addition, p39 can colocalize with actin, suggesting that p39 plays a role in regulating actin cytoskeletal dynamics in cells.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of CDK5R2. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 71-122 of Human CDK5R2.
