Cdk10, also called PISSLRE, is a Cdc2-related kinase whose gene has been shown to encode two isoforms, each having a different function within the cell cycle.
Although the two isoforms share nearly identical amino acid seqeunces, they differ at the C- and N- terminals.
One Cdk isoform interacts with the transcription factor Ets-2, thereby modulating its transactivation activity, while the other is thought to have a role at the G2/M transition.
Cdk10 mRNA has been shown to have the highest expression in lung, liver and kidney tissue, with gene upregulation implicated in cases of non-Hodgkin’s follicular lymphoma.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of CDK10. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 30-84 of Human Cdk10.
