The T cell receptor (TCR) is a heterodimercomposed of either alpha and beta or y and delta chains.
CD3 chains and the CD4 or CD8 co-receptors are also required for efficientsignal transduction through the TCR.
The TCR is expressed on T helper and T cytotoxiccellsthatcan be distinguished bytheir expression of CD4 and CD8.
T helpercells express CD4 proteins and T cytotoxiccells display CD8.
CD8 (also designated Leu 2 or T8), a cellsurface glycoprotein, is a two chain complex(alphaalpha or alphabeta) receptor that bindsclassI MHC molecules presented bythe antigen-presenting cell (APC).
A primaryfunction of CD8 is to facilitate antigen recognition bythe TCR and to strengthen the avidity of the TCR-antigen interactions.
An additional role for CD8-expressing T cellsmay be tomaintain lowlevels of HIV expression.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 15mM sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of CD8B. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to residues in Human CD8B.
