The T cell receptor (TCR) is a heterodimer composed of either alpha and beta or y and delta chains.
CD3 chains and the CD4 or CD8 co-receptors are also required for efficient signal transduction through the TCR.
The TCR is expressed on T helper and T cytotoxic cells that can be distinguished by their expression of CD4 and CD8.
T helper cells express CD4 proteins, while T cytotoxic cells display CD8.
CD8 (also designated Leu-2 or T8), a cell surface glycoprotein, is a two chain complex (alphaalpha or alphabeta) receptor that binds class I MHC molecules presented by the antigen-presenting cell (APC).
A primary function of CD8 is to facilitate antigen recognition by the TCR and to strengthen the avidity of the TCR-antigen interactions.
An additional role for CD8-expressing T cells may be to maintain low levels of HIV expression.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of CD8A. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to residues in Human CD8A.
